The Superiority of SDMA as a Renal Function Biomarker and Its Role in the Detection of Early - stage Chronic Kidney Disease.
1. SDMA is primarily excreted by the kidneys, thus serving as a biomarker for renal function impairment.
2. When the glomerular filtration rate decreases by 40%, the SDMA level commences to rise, and an elevation can be noticed even when the rate is reduced by at least 25%.
3. Compared with creatinine, SDMA can identify chronic kidney disease at an earlier stage, approximately 9.5 months earlier in dogs and 17 months earlier in cats.
4. SDMA is not influenced by extrarenal factors, such as low body weight, liver diseases, Cushing's syndrome, and heart diseases.
